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PF-2545920 hydrochloride

CAS No. ——

PF-2545920 hydrochloride( Mardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride )

Catalog No. M16961 CAS No. ——

A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-2545920 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
  • Description
    A potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.Schizophrenia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Mardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    428.9135
  • Molecular Formula
    C25H21ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    ——
  • Chemical Name
    Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,hydrochloride(1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Verhoest PR, et al. J Med Chem. 2009 Aug 27;52(16):5188-96. 2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90. 3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
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